Insilico analysis of the MRP1 Protein implicated in Neuroblastoma

MRP1 is a uni-directional efflux transporter that confersmultidrug resistanceand mediates the effluxof both endobiotic andxenobiotic organicanions. MRP1 transports many therapeutic and physiological substrates. It has a key role in the onset of drug resistance in several cancers for example lung, breast, prostate, and childhood neuroblastoma. In the present work, the wild type and mutant protein sequence of MRP1 protein were analysed using an insilico approach for studying the functional role of the MRP1 protein in the normal and diseased condition. The variation in the mutant protein was analysed at the structural level to decipher the mode of the disease progression.